The first NHS-commissioned specialist brachial plexus service for the South West — serving Bristol, Gloucestershire, Somerset, Dorset, Devon, Cornwall, Wiltshire and beyond. We support 20 NHS Trusts and Foundation Trusts across a population of 8.5 million people.
Coordinated care tailored to your diagnosis — surgeons, therapists, radiologists and nurses working as one team.
Diagnostics, surgery, therapy and rehabilitation — all connected, from first referral to long-term recovery.
Active in national and international studies. Every patient offered the opportunity to contribute to future care.
Information about your injury, what to expect, and how we can help.
Read more →Physiotherapy, occupational therapy, and links to patient communities.
Read more →Help us improve care for everyone with a nerve injury.
Read more →Kid-friendly information with Axon the axolotl.
Read more →A dedicated multidisciplinary team of clinicians, researchers and administrators — united by a shared commitment to the best possible outcomes for every nerve injury patient in the South West.
For too long, patients with brachial plexus injuries in the South West faced a difficult journey — long distances out of region, unfamiliar teams, and fragmented care. SWePT was established to change that.
Based at Southmead Hospital, we bring together surgeons, therapists, radiologists, neurophysiologists and specialist nurses under one coordinated service — working hand-in-hand with your regional hospital and therapy team.
We value transparency and partnership. Every patient and family is kept informed and involved at every step. Recovery is a shared effort, and we believe in your active role in your own care.
We also lead and collaborate in national and international research, so that the latest evidence always reaches the patients who need it most.
A wide multidisciplinary team of clinicians and administrators, united by a shared commitment to the best possible outcomes for nerve injury patients across the South West.
This page explains what that means, what to expect, and how SWePT will support you — from your first appointment through to your recovery.
The brachial plexus is a complex network of nerves running from your spine, through your neck and shoulder, and down into your arm and hand. These nerves control everything your arm and hand does — movement, sensation, temperature, and pain.
When the brachial plexus is injured — through a road traffic accident, a fall, surgery, or another cause — it can result in weakness or paralysis, loss of sensation, and neuropathic pain. Recovery depends on the severity and location of the injury.
Nerves regenerate slowly — at roughly 1mm per day — so recovery is measured in months and years, not days or weeks. This can be difficult to live with, and we are here to support you throughout.
The arm, hand, or shoulder may be weak or unable to move, depending on which nerves are affected.
Burning, shooting, stabbing or electric-shock pain — often felt in the arm or hand.
The skin may feel numb, tingly, or hypersensitive.
Joints can stiffen quickly when not moving normally. Early therapy is important.
Neuropathic pain is one of the most challenging aspects of a brachial plexus injury. It is caused by damage to the nerves themselves — and can feel very different from ordinary pain: burning, shooting, stabbing, electric, or like a deep ache that does not go away.
Importantly, neuropathic pain does not mean your recovery is going badly. It is a sign that your nervous system is active — though that does not make it any less real or difficult to live with.
What helps?
Always discuss any new or worsening pain with SWePT.
If surgery is recommended, it will take place at Southmead Hospital. Options include nerve repair, nerve grafting, nerve transfer, neurolysis, or thoracic outlet decompression — depending on your injury.
You will be seen in pre-assessment clinic. Bring a list of medications. Most operations require a general anaesthetic and you will usually be admitted on the morning of surgery.
Most operations last 2–6 hours. You will be monitored closely in recovery. Many patients go home the same day; some stay overnight. The nursing team will guide you.
You will receive specific written instructions for your operation type. Nerves regenerate at ~1mm per day so it may take many months before you see the benefit. Download your post-operative guide from the Downloads page.
Physiotherapy and occupational therapy are at the heart of recovery from a brachial plexus injury. Our therapists at SWePT work with you and your local team throughout your journey.
Maintaining joint range of movement, building strength as nerve function returns, managing pain through movement, and guided exercise programmes tailored to your surgery and recovery stage.
Helping you adapt daily activities and return to work, driving, and leisure. Specialist splinting, equipment provision, and functional training to maximise independence.
Our SWePT therapists — Hazel Brown (Consultant Therapist), Antonia Hook (Physiotherapist), Fiona Powell (Occupational Therapist), and Cat Rolls (Academic Physiotherapist) — work closely alongside the surgical and nursing team.
Your local therapy team plays a vital role too. SWePT provides detailed post-operative guidelines and works in communication with your regional therapists so your rehabilitation is joined up, wherever you are in the South West.
Connecting with others who understand what you are going through can make a real difference. These organisations offer peer support, information, and community.
The Traumatic Brachial Plexus Injury Group — a patient-led community for adults living with brachial plexus injury. Forums, peer support, events and lived-experience resources.
tbpi-group.co.uk →Support and information for families affected by obstetric (birth-related) brachial plexus injury. Events, helpline, and peer network.
erbspalsy.org.uk →Living with a chronic injury affects mental health too. NHS Talking Therapies offers free psychological support — ask your GP or contact SWePT to be referred.
nhs.uk →NHS pain management resources, including advice on medication, pacing, and living well with chronic pain.
NHS Live Well →The Access to Work scheme may fund adaptations and support if your injury affects your ability to work.
Gov.uk Access to Work →DVLA guidance on driving with a disability, and how to apply for an adapted vehicle assessment.
DVLA guidance →SWePT leads and collaborates in national and international research. Taking part does not change your clinical care — but it could change the lives of future patients.
In September 2024, the NIHR James Lind Alliance (JLA) Priority Setting Partnership in Adult Traumatic Brachial Plexus Injury — led by the team now constituting SWePT together with the UCL Centre for Nerve Engineering, with input from all major UK plexus centres and the TBPI patient community — published the Top 10 research priorities for this condition.
These priorities were identified from more than 600 responses from patients, carers, and clinicians. SWePT was central to delivering this work and every study we undertake is designed to address these priorities directly, in partnership with the patients who will benefit from the answers.
Our research is conducted in collaboration with leading academic institutions:
We work with the University of Bristol Biomedical Research Unit (BRU), the UCL Centre for Nerve Engineering, and NDORMS Oxford to translate research findings into benefits for patients.
Nerve Injury Community Days — bringing together patients, researchers, and clinicians. Illustrations by Esther Sketches / Jenny Leonard Art.
We aim to offer every patient the opportunity to contribute to research. Participation is always voluntary and never affects the care you receive.
What is REPAIR?
REPAIR is the first national long-term database — a registry and biobank — for patients with brachial plexus injuries and related conditions in the UK. It is led by Mr Tom Quick and the SWePT team at Southmead Hospital, sponsored by North Bristol NHS Trust and hosted by the University of Bristol.
The study will collect clinical information, patient-reported outcomes, and — with your separate consent — small biological samples to help us understand what happens to patients over time and develop better treatments.
Who can take part?
Patients of all ages with a confirmed brachial plexus injury or related condition — including traumatic brachial plexus injury, birth-related brachial plexus injury, neurogenic thoracic outlet syndrome, and Parsonage-Turner syndrome.
What does taking part involve?
No extra hospital visits. We collect information from your routine NHS care and ask you to complete short questionnaires about how your condition affects your life — at the time of your referral, and at 4 months, 12 months, 2 years, 5 years, and beyond.
What are you consenting to?
Your data is held securely and will never identify you personally. Your clinical care will not be affected in any way by your decision to take part or not.
Neurogenic thoracic outlet syndrome (nTOS) is caused by compression of the brachial plexus in the lower neck. Variations in bone anatomy — including cervical ribs and C7 transitional vertebrae — are thought to be important contributing factors, but the exact relationship is poorly understood.
This study uses X-ray and CT imaging to characterise the anatomical variants present in patients with confirmed nTOS, to help us better understand who is at risk and improve how we diagnose and treat the condition.
In collaboration with RUDI (Rare and Undiagnosed Diseases Initiative), this study analyses tissue removed during thoracic outlet decompression surgery to understand the underlying pathological changes that cause compression of the brachial plexus in nTOS.
Understanding what is happening at a cellular level will help us develop better diagnostic tests and more targeted treatments. Tissue for this study is collected from operations — material that would otherwise be discarded.
There is currently no blood test that can tell us how severely a nerve has been injured or how well a patient will recover. This study investigates circulating biological markers — including neurofilament light chain (NfL) and other candidate proteins — that may reflect the degree of nerve damage (axonopathy) in patients with brachial plexus injury.
If validated, such biomarkers could transform how we assess nerve injuries and monitor recovery — without the need for invasive investigations. Blood samples are collected alongside routine clinical appointments.
Brachial plexus injury affects approximately 0.17 to 1.6 per 100,000 people per year in England — comparable in scale to ovarian or stomach cancer, but with consequences that are frequently lifelong. Yet it has received relatively little research attention.
There is currently no single diagnostic test that can confirm the severity of a nerve injury; no blood test that tells us how well a patient will recover; and no medication that helps nerves regenerate. REPAIR and our partner studies are designed to change this.
The NIHR JLA Top 10 research priorities — which SWePT helped deliver — identified establishing a national registry and biobank as a top priority. REPAIR is the direct response to that call, and provides the infrastructure through which all 10 priorities can be systematically addressed over the coming decades.
James Lind Alliance → UCL Centre for Nerve Engineering →All our patient information sheets and post-operative rehabilitation guidelines in one place. Download and share with your therapy team.
Introduction to your injury and what to expect from care with SWePT.
What TOS is, how it is diagnosed, and treatment options including surgery.
What nerve pain is, why it happens, and how to manage it.
Wound care, scar massage, and general advice after nerve surgery.
These clinical guidelines are for patients and their therapy teams. Your operation note always takes precedence — please follow any specific instructions given by your surgeon.
Phased rehabilitation following nerve transfer to re-innervate elbow flexion.
Guidelines for nerve transfer to the deltoid for shoulder elevation.
Guidelines for spinal accessory to suprascapular nerve transfer.
Post-operative rehabilitation following nerve exploration and neurolysis — upper limb.
Post-operative guidelines for lower limb nerve exploration and neurolysis.
Post-operative rehabilitation following neurogenic thoracic outlet decompression.
Refer patients directly to SWePT via Signpost Healthcare. Available 24/7.
Signpost Healthcare →For clinical queries, urgent referrals, or to discuss a patient, email SWePT directly.
swept@nbt.nhs.ukInterested in involving your centre in REPAIR? Contact Mr Tom Quick to discuss.
swept@nbt.nhs.ukWhether you are a child or young person with a brachial plexus injury, or a parent trying to understand what happened to your baby — Axon is here to help explain it all.
Axolotls are amazing — we are one of the only animals in the world that can regrow our nerves after they are injured. That makes me the perfect guide to help you understand nerve injuries and how they heal!
🌟 Fun fact: Axolotls can regrow entire limbs, hearts, and even parts of their brain. Scientists study us to learn how to help people heal from nerve injuries — including the kind the SWePT team treats!
Think of nerves like the wiring in your body
Your brain wants to move your arm. It sends a message — like a text — down a wire called a nerve.
The message travels from your brain, through your neck and shoulder, and all the way down your arm to your muscles.
Your muscle gets the message and moves. That is how you pick things up, wave, or throw a ball!
Nerves also send messages the other way — telling your brain what you can feel, like if something is hot, cold, or sharp.
🧠 The brachial plexus is a bundle of nerves in your neck and shoulder that controls your whole arm. Imagine a bunch of cables running from your spine to your fingers. That is the brachial plexus!
When a nerve is injured, it needs time to grow back. Nerves grow at about 1mm every day — that is the width of a match! So patience is really important — and the SWePT team will be with you every step of the way.
For parents and families — what happened and what to expect
During a difficult delivery, the nerves in your baby's neck and shoulder can be stretched or torn. It can happen when the baby's shoulder gets stuck, or when the neck is stretched. It is not your fault — it is a complication of a difficult birth.
Many babies recover very well — some completely, some with some lasting weakness. The degree of recovery depends on how severely the nerves were injured. Your SWePT team will examine your baby on several occasions and use special tests to help predict recovery and whether surgery could help.
Many young people with birth-related brachial plexus injury are highly active — excelling in sport, school, and life. With the right support, therapy, and — if needed — surgery, the outlook for most children is positive.
🔬 How nerve surgery works: "Nerve surgery is not like wiring up a light bulb — nerves are more like a hosepipe. When you turn the tap on (surgery), water does not appear at the other end immediately. It has to creep along slowly — just like how nerves regrow towards the muscles."
You do not have to figure this out alone
A charity supporting families affected by birth-related brachial plexus injury. Helpline, events, peer support, and information for parents and young people.
erbspalsy.org.uk →Detailed parent's guide to obstetric brachial plexus palsy written by Mr Tom Quick — one of the SWePT surgeons. Covers the condition, surgery, and what to expect.
Parent's guide →If you have questions that are not answered here — or you just want to speak to someone — please get in touch. We are here for you and your family.
We have compiled answers to the questions we hear most often. If you cannot find what you are looking for, please contact us directly.
Whether you are a patient, family member, referring clinician, or colleague — we are here to help.
Southmead Hospital switchboard
0117 950 5050
For clinical referrals use the Signpost portal.
For clinical queries, general enquiries, and patient support. Our secretary Lisa Rothery manages the team inbox and will direct your message to the right person.
swept@nbt.nhs.uk⚠ This email is not monitored continuously and is not for clinical information or referrals. For urgent concerns call Southmead Hospital switchboard 0117 950 5050. For referrals use the Signpost form.
Referrals to SWePT are made online via Signpost Healthcare. Available 24/7 for GPs and hospital clinicians.
signpost.healthcare →Southmead Hospital
Brunel Building
Southmead Road
Bristol, BS10 5NB
We collaborate with the North Bristol NHS Trust and maintain links with regional hospitals across the South West.
SWePT is not an emergency service. If you have an urgent concern after surgery — including signs of wound infection — contact your GP, call NHS 111, or in an emergency call 999 or attend A&E.
You may also email swept@nbt.nhs.uk (not for urgent concerns) and we will respond as soon as possible during working hours.
To find out more about REPAIR or any of our studies, or to express interest in participating or collaborating, please email the team directly.
swept@nbt.nhs.uk →A complex condition where nerves of the brachial plexus are compressed in the lower neck. SWePT is the specialist centre for assessment, rehabilitation and surgery for nTOS across the South West.
The thoracic outlet is a named anatomical region — like the carpal tunnel — that sits at the base of the neck, between the collarbone and the first rib. Running through this corridor are the brachial plexus (the network of nerves controlling all movement and sensation in the arm and hand), and the subclavian artery and vein.
Thoracic outlet syndrome (TOS) occurs when these structures are compressed, stretched, or tethered within this space. It is not one condition — it is three, grouped by which structure is affected.
The brachial plexus nerves are compressed or tethered. This is the type SWePT specialises in. Symptoms include pain, numbness, tingling, weakness, and heaviness anywhere in the arm.
The subclavian vein is compressed, causing swelling and heaviness. May cause blood clotting (Paget–Schroetter syndrome).
The subclavian artery is compressed. The rarest and most serious form — most often associated with a cervical rib.
nTOS can affect any of the nerves of the brachial plexus — so symptoms vary considerably from patient to patient depending on which parts of the plexus are compressed.
Burning, aching, shooting, or electric pain in the arm, shoulder, or neck. Often worse with arm elevation or sustained overhead activity. Can affect the hand, inner arm, or areas behind the shoulder.
Altered sensation in any part of the arm or hand, depending on which nerve roots are affected. The inner forearm and little-finger side of the hand are commonly involved, but the whole limb may be affected.
Arm heaviness or weakness with sustained activity. Hand weakness in more established cases. In severe or longstanding nTOS, visible wasting of the small muscles of the hand can occur (true neurogenic TOS).
In most patients, nTOS arises from a congenital predisposition — the way the nerves, muscles, and surrounding structures developed during embryology. A precipitating event — often a whiplash injury, fall, or period of repetitive overhead activity — then brings the underlying susceptibility to the surface.
nTOS is more common in women aged 20–50, though it can affect anyone. The wide range of reported prevalence (3–80 per 1,000 people) reflects the genuine difficulty in diagnosis rather than true epidemiological uncertainty.
Ligamentous or fascial bands running from a cervical rib or C7 transverse process to the first rib, crossing the lower trunk of the brachial plexus.
Variant muscle anatomy — nerve roots running through the anterior scalene, conjoint muscles with no interval, or a 'scalene sickle' trapping the lower trunk.
Compression from the paraneurium or enveloping fascia around the plexus — producing tethering even without bony or muscular abnormality.
Bony anomalies at C7 — a full cervical rib, a rudimentary rib, or a C7 transitional vertebra — which narrow the thoracic outlet and increase the risk of neurovascular compression.
nTOS is a clinical diagnosis of exclusion — reached through careful history-taking and physical examination, supported by investigations that help rule out other conditions. There is no single test, scan, or measurement that confirms nTOS. The diagnosis emerges from the pattern of symptoms, their relationship to posture and arm position, the exclusion of other causes, and — in some cases — the response to treatment.
Provocation tests — such as the elevated arm stress test (Roos test), Adson's test, and the Upper Limb Tension Test — can reproduce characteristic symptoms and support the diagnosis. A Tinel sign over the scalene triangle (tingling radiating into the arm when tapped) is a useful positive finding when present.
Importantly, a normal neurophysiology result does not exclude nTOS. Nerve conduction studies are frequently normal in nTOS, particularly in early and intermediate stages. Their primary value is in ruling out other peripheral nerve conditions such as carpal tunnel or cubital tunnel syndrome.
Identify cervical ribs, C7 transitional anatomy, and other bony variants that narrow the thoracic outlet.
Can show plexus tenting, crowding, or perineural signal change — though a normal MRI does not exclude nTOS.
Frequently normal in nTOS. Primarily used to exclude other peripheral nerve conditions that may mimic or coexist with TOS.
Dynamic ultrasound of the scalene triangle can identify muscular anomalies and areas of nerve compression or angulation with arm movement.
Ultrasound, CT angiography or venography if arterial or venous involvement is suspected.
Treatment follows a structured pathway — starting with conservative management and moving to surgery only when there is clear evidence that conservative measures have been genuinely tried and surgery can offer meaningful improvement.
The foundation of nTOS management. This is where the patient does the work — and it can produce meaningful, lasting improvement.
When symptoms persist despite a genuine trial of physiotherapy and analgesia, surgery becomes a consideration. The SWePT team will review your full clinical picture, imaging, and neurophysiology results before recommending surgery.
Surgery allows the thoracic outlet to be explored directly, the compressive anatomy to be identified, and — if found — corrected. In the majority of cases, meaningful improvement follows.
Surgery frees the nerve; rehabilitation allows recovery to consolidate. Post-operative physiotherapy, occupational therapy, and pain medicine support all contribute to the best possible outcome.
Most patients are clearly improved by 3 months after surgery. The SWePT team follow up personally to monitor progress and adjust management as recovery develops.
You will be monitored in recovery for 1–2 hours, then transferred to the ward. You will have a drip in your arm (removed once you are drinking), and a drain near the wound (usually removed the next morning). You can have a light meal later in the day.
Most patients stay one night in hospital. Occasionally a longer stay is needed. You will have been seen in pre-assessment clinic before your admission.
The most common risk. The majority of patients do experience improvement, but surgery cannot be guaranteed to work in every case.
May require antibiotics or, rarely, reopening the wound. Contact SWePT and your GP if you notice signs of infection.
The thoracic outlet is a confined space closely related to several important nerves and blood vessels. Your surgeon will protect these at all times. Serious injury is rare but possible and will be discussed with you before the operation.
Surgery is not a cure for an underlying anatomical predisposition — it addresses the structural causes of compression. For some patients, ongoing attention to posture, exercise, and activity modification remains important beyond recovery. The SWePT team will give you an honest assessment of what is achievable in your specific case.
Some neuropathic pain may persist after surgery, particularly if the nerves have been compressed for a long time. Pain management support from our colleagues — including Dr Jim Dunham — is available throughout recovery.
Nerve pain is one of the most challenging aspects of a brachial plexus injury or TOS. This page explains what it is, why it happens, and the practical steps you can take to manage it — with support from the SWePT team.
Neuropathic pain is caused by damage to or abnormal signalling within the nerves themselves — not by injury to the tissues around them. This makes it feel very different from ordinary pain, and means that ordinary painkillers such as paracetamol or ibuprofen often provide little benefit.
People describe it as burning, shooting, stabbing, electric, or like a deep ache that does not go away. It can be constant or come in waves. It is often worse at night, when you are tired, or when you are stressed. Cold can make it worse; warmth sometimes helps.
Importantly: neuropathic pain does not mean your recovery is going badly. It is a sign that your nervous system is active — though that does not make it any less real or less difficult to live with.
There is no single solution. The evidence strongly supports combining approaches — physical, psychological, and medical — rather than relying on any one treatment alone.
These work on the nervous system rather than on tissues, which is why ordinary painkillers are less effective.
These medicines take 2–4 weeks to reach full effect. Side effects are common initially but often settle. Do not stop suddenly without advice from your doctor.
Movement is medicine — even when it is painful to start. Guided by your therapist.
The nervous system is affected by everything — sleep, stress, activity, and mood. These approaches address the whole person.
SWePT works closely with Dr Jim Dunham, Consultant in Pain Management at North Bristol NHS Trust. For patients whose pain is not adequately controlled through the approaches above, referral to the pain service can provide:
If you feel your pain is not well controlled, please tell us. We can arrange a referral to the pain service alongside your ongoing surgical and therapy care.
Recording your pain on a simple scale (0–10) each day — noting what makes it better or worse, how it affects your sleep, and what you were doing — gives your clinical team valuable information and can help you identify patterns and triggers.
Chronic nerve pain can persist even when the nerves are healing. Pain is a signal produced by the nervous system — and in neuropathic conditions that system is misfiring. Having pain does not mean you are injuring yourself by moving or exercising.
Neuropathic pain typically reduces as nerve regeneration progresses — but this can take many months. Being patient with the process while actively engaging with all available treatments gives you the best chance of improvement.
Peer support from others living with traumatic brachial plexus injury — including advice on managing pain from those with lived experience.
tbpi-group.co.uk →The NHS Live Well pages on chronic pain — including advice on pacing, medication, and self-management strategies.
NHS Live Well →If your pain is not well controlled, or you have questions that are not answered here, please get in touch. We are here to help.
swept@nbt.nhs.ukLumps that arise within or near a nerve. Most are entirely benign. This page explains what nerve tumours are, how they are recognised and diagnosed, and when — and whether — treatment is needed.
The word tumour is alarming — but in medicine it simply means a lump or growth. Nerve tumours are lumps that arise from within a nerve. The overwhelming majority are benign: they are not cancer, they do not spread, and they are not dangerous to life.
The most common type is called a Schwannoma. It grows from a Schwann cell — a specialised cell that normally wraps around nerve fibres to insulate them. The lump develops inside the outer lining of the nerve, pushing the normal nerve fibres aside rather than destroying them, which is why surgery can usually remove it without lasting damage to the nerve.
A less common type is a neurofibroma, which is more intimately woven into the nerve fibres themselves. The vast majority of these are also benign.
Most people discover a nerve tumour by noticing a lump — perhaps when washing, or because pressing on a particular spot is slightly uncomfortable or produces an odd tingling further along the arm or leg. The lump may have been there for years without causing any trouble.
There are features that are very characteristic of a nerve tumour:
Tapping directly over the lump sends a tingling sensation into the part of the body that nerve supplies. This is called a positive Tinel sign, and it is a highly reliable indicator that the lump is arising from a nerve.
The lump can be moved sideways across the line of the nerve, but not along it — because it is tethered within the nerve itself.
The lump may be mildly tender, or ache when knocked. It should not be severely painful at rest.
After a clinical examination, an MRI scan is the most helpful investigation. On MRI a Schwannoma has a very characteristic appearance — usually an oval mass sitting in line with the nerve, sometimes with a visible "tail" where the nerve enters and exits. The combination of clinical findings and MRI allows a confident diagnosis in around 98% of cases.
No needle biopsy is recommended. Passing a needle through the nerve to sample the lump risks damaging the surrounding healthy nerve fibres, causing pain that can persist long after the biopsy. The only way to be absolutely certain is to remove the lump surgically — which is also the treatment.
Not necessarily. If the lump is small, the symptoms are mild, and the MRI is typical, it is entirely reasonable to monitor without operating. The decision depends on what matters to you.
Even with an excellent MRI, a small residual uncertainty may remain. If that is not acceptable, removal and histological examination gives a definitive answer.
If pain, tenderness, or tingling are affecting your daily life, removing the lump usually relieves or resolves these symptoms.
Any significant change on interval imaging warrants a closer look. A lump that is growing needs assessment even if it was previously being observed.
After a full discussion of risks and alternatives, an informed decision to proceed is a valid reason in itself.
Unlike Schwannomas, neurofibromas are more intimately woven into the nerve fibres and cannot simply be shelled out. Excision requires removal of the involved fascicle. Surgery is considered only when symptoms are significant or growth is concerning.
Temporary post-operative tingling or numbness in the nerve's territory is common and expected. Most patients find their symptoms improve significantly after recovery. You will be given full written information before and after the operation.
Neurogenic tumours can present to any surgical service. Their relative rarity leads to uncertainty in recognition and management — and the need for referral is often underestimated. The differential for any soft tissue mass includes all tissue types, and neural origin should not be omitted.
A multidisciplinary approach applies as with all tumours. However, when clinical examination and MRI appearances are classical, many neurogenic tumours — particularly Schwannomata — can be managed without prior histological confirmation.
| Tumour type | Nature | Key features | Biopsy? | Management | Refer? |
|---|---|---|---|---|---|
| Schwannoma | Benign | Most common. Encapsulated, eccentrically placed. Shelling out usually possible without fascicular sacrifice. | Not recommended | Monitor or open excisional biopsy | Peripheral nerve unit |
| Neurofibroma | Benign / watch | Multiple cell types. Plexiform variant: 8–13% lifetime malignant transformation risk. Cannot be shelled out. | Not usually required | Monitor; excise if symptomatic | If multiple / NF1 |
| MPNST | Malignant | Aggressive sarcoma. NF1 association. Rapidly growing, painful. Radical excision with clear frozen-section margins. | Staging biopsy | Radical excision + MDT (radio/chemo) | Yes — urgent, sarcoma MDT |
| Glomus tumour | Benign | Subungual location. Cold hypersensitivity + point-localised pain are classical. 1–5% of hand tumours. | Not required | Surgical excision, preserve NV structures | Hand surgery unit |
Examination of any soft tissue mass should characterise size, location, skin relationship, transillumination, and — crucially — the Tinel sign. This is frequently omitted and yet pathognomonic of a neurogenic origin.
Percussion of the tumour produces paraesthesiae in the distal territory of the affected nerve. The lump is additionally characterised by mobility in the transverse axis but not the longitudinal axis of the nerve — owing to its intraneural origin.
The history should document comorbidities, any family history of tumour conditions (notably neurofibromatosis), duration and progression of symptoms, and the presence or absence of motor deficit.
Round or oval mass with a visible fascicular "tail". Moderately bright on T1; bright heterogeneous T2 signal; uniform gadolinium enhancement. PET shows avid, uniform FDG uptake.
Needle biopsy risks fascicular damage and intraneural scarring, produces persistent pain, and frequently fails to yield sufficient tissue. Scarring also complicates subsequent open surgery.
Careful open excisional biopsy under magnification. The involved non-functional fascicle containing the tumour is excised. Transient post-operative neurapraxia should be anticipated and discussed pre-operatively.
Neurofibromata arise from non-myelinating Schwann cells via bi-allelic inactivation of the NF1 gene (neurofibromin), disrupting RAS-mediated cell growth signalling. Unlike Schwannomata they incorporate multiple cell types and are not amenable to shelling out — excision requires fascicular sacrifice.
Dermal neurofibromata (single peripheral nerve) do not undergo malignant transformation. Plexiform neurofibromata (multiple nerve bundles) carry a lifetime transformation risk of 8–13% to MPNST, and surveillance programmes using PET imaging are employed to monitor metabolic activity.
Avid FDG uptake is highly suggestive of transformation and mandates grading, staging, and radical surgical excision. In the UK, patients with NF1 may be referred to the national specialist centre at Guy's and St Thomas' Hospital, London.
MPNSTs are aggressive soft-tissue sarcomas with a high rate of local recurrence and metastasis. NF1 association is well established (lifetime risk 8–13%). Presentation is typically a rapidly growing mass with pain, paraesthesiae, or motor deficit.
MRI and CT define extent but cannot reliably distinguish benign from malignant. FDG PET is the investigation of choice for this distinction.
As a general principle, biopsy is not required when clinical and radiological findings collectively indicate a benign peripheral nerve tumour. Percutaneous biopsy of neurogenic tumours risks damage to intact uninvolved fascicles, frequently fails to return sufficient tissue for a firm diagnosis, and creates intraneural scarring that causes patient morbidity and complicates any subsequent open surgery.
The exception is borderline FDG PET uptake in a plexiform neurofibroma, where percutaneous biopsy may be appropriate to guide the decision between continued surveillance and radical excision.
Communication with a regional peripheral nerve injury unit will in most cases lead to more expert management and a better outcome for the patient. SWePT accepts referrals for nerve tumours of the brachial plexus region from across the South West.